380315-80-0
380315-80-0
Chemical Structure
Tenovin-1
- CAS No.: 380315-80-0
- Formula:C20H23N3O2S
- Molecular Weight:369.48
IUPAC Name: N-((4-acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide
InChIKey: WOWJIWFCOPZFGV-UHFFFAOYSA-N
SMILES: O=C(NC(NC1=CC=C(NC(C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2
Biological Activity: Tenovin-1, a p53 activator, protects p53 from MDM2-mediated degradation. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tenovin-1 | 99.88% | Tenovin-1, a p53 activator, protects p53 from MDM2-mediated degradation. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor. | ||||||||||||||||||||
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References
- [1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008;13(5):454-463. [Content Brief]
- [2]. Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8]. J Biol Chem. 2020;jbc.RA119.012056. [Content Brief]
Keywords
