385419-89-6
Chemical Structure
MMV085203
- CAS No.: 385419-89-6
- Formula:C22H22N2O3
- Molecular Weight:362.42
InChIKey: SKHLQEYQHYUBHY-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(C(N3CCCCC3)=C1NC4=C(OC)C=CC=C4)=O)C=CC=C2
Biological Activity: MMV085203 is a potent Plasmodium falciparum inhibitor, with a PfTrxR EC50 of 900 nM. MMV085203 exerts potent antimalarial activity against both blood‑stage and sexual‑stage Plasmodium falciparum parasites, with superior efficacy toward clinical isolates of high clonal diversity. MMV085203 modulates parasite redox homeostasis, induces ROS production, and elevates mitochondrial TCA cycle intermediates. MMV085203 can be used for the research of malaria[1][2].
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MMV085203 | MMV085203 is a potent Plasmodium falciparum inhibitor, with a PfTrxR EC50 of 900 nM. MMV085203 exerts potent antimalarial activity against both blood‑stage and sexual‑stage Plasmodium falciparum parasites, with superior efficacy toward clinical isolates of high clonal diversity. MMV085203 modulates parasite redox homeostasis, induces ROS production, and elevates mitochondrial TCA cycle intermediates. MMV085203 can be used for the research of malaria. | |||||||||||||||||||||
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- [1]. Rocamora F, et al. PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum. ACS Infect Dis. 2021 Apr 9;7(4):811-825. [Content Brief]
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[2]. Chirawurah JD, et al. MMV006087 is a potent Malaria Box compound against Plasmodium falciparum clinical parasites. Front Drug Discov. 2023;3:1190471.
Keywords
