40594-09-0
Chemical Structure
Flucindole
- CAS 番号: 40594-09-0
- Formula:C14H16F2N2
- Molecular Weight:250.29
IUPAC Name: 6,8-difluoro-N,N-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-3-amine
InChIKey: FXNCRITWFOVSEP-UHFFFAOYSA-N
SMILES: FC=1C=C(F)C=2NC3=C(C2C1)CC(N(C)C)CC3
Biological Activity: Flucindole is an orally active dopamine receptor inhibitor (IC50 = 240 nM) that also exhibits affinity for S2 receptors. Flucindole inhibits amphetamine-induced stereotyped behaviors in rats, and increases the levels of dopamine metabolites in the striatum of rats and mice. Flucindole can be used in the research of psychosis[1][2].
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Flucindole | Flucindole is an orally active dopamine receptor inhibitor (IC50 = 240 nM) that also exhibits affinity for S2 receptors. Flucindole inhibits amphetamine-induced stereotyped behaviors in rats, and increases the levels of dopamine metabolites in the striatum of rats and mice. Flucindole can be used in the research of psychosis. | |||||||||||||||||||||
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- [1]. Edelson J, et al. Disposition of a series of tetrahydrocarbazoles. Drug metabolism reviews. 1980;11(2):263-89. [Content Brief]
- [2]. Wood PL, et al. Ciclindole and flucindole: novel tetrahydrocarbazolamine neuroleptics. Progress in neuro-psychopharmacology & biological psychiatry. 1984;8(4-6):773-7. [Content Brief]
Keywords
