408358-51-0
Chemical Structure
Procumbenoside A
- CAS No.: 408358-51-0
- Formula:C31H32O15
- Molecular Weight:644.58
IUPAC Name: 9-(benzo[d][1,3]dioxol-5-yl)-4-(((2S,3R,4R)-4-hydroxy-4-(hydroxymethyl)-3-(((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-2-yl)oxy)-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one
InChIKey: HBUCXSOGVZJQHH-IJZDSENBSA-N
SMILES: O=C1C2=C(C=3C(C(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O)CO5)[C@](CO)(O)CO4)=C2CO1)=CC(OC)=C(OC)C3)C=6C=C7C(=CC6)OCO7
Biological Activity: Procumbenoside A is a lignan glycoside discovered in Justicia procumbens. Procumbenoside A inhibits HIV-1 replication with an IC50 of 4.95 μM. Procumbenoside A exerts cytotoxic effects on various cancer cells. Procumbenoside A induces Cu (II)-mediated strand breaks in supercoiled plasmid DNA, generating the relaxed circular DNA form, while no linear form is detected. Procumbenoside A is used in studies related to liver cancer, colon adenocarcinoma, and HIV-1 infection[1][2][3].
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Procumbenoside A | Procumbenoside A is a lignan glycoside discovered in Justicia procumbens. Procumbenoside A inhibits HIV-1 replication with an IC50 of 4.95 μM. Procumbenoside A exerts cytotoxic effects on various cancer cells. Procumbenoside A induces Cu (II)-mediated strand breaks in supercoiled plasmid DNA, generating the relaxed circular DNA form, while no linear form is detected. Procumbenoside A is used in studies related to liver cancer, colon adenocarcinoma, and HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Day SH, et al. Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. Journal of natural products. 2002 Mar;65(3):379-81. [Content Brief]
- [2]. Xu XY, et al. Anti-HIV lignans from Justicia procumbens. Chinese journal of natural medicines. 2019 Dec;17(12):945-952. [Content Brief]
- [3]. Lu YH, et al. DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants. Phytochemistry. 2008 Jan;69(1):225-33. [Content Brief]
