42021-34-1
Chemical Structure
Biriperone
Synonym(s): Centbutindole
- CAS No.: 42021-34-1
- Formula:C24H26FN3O
- Molecular Weight:391.48
IUPAC Name: 1-(4-fluorophenyl)-4-(3,4,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-2(1H)-yl)butan-1-one
InChIKey: YCNCIZWAGQTWBI-UHFFFAOYSA-N
SMILES: O=C(C(C=C1)=CC=C1F)CCCN2CC3CC4=C(CN3CC2)NC5=CC=CC=C45
Biological Activity: Biriperone is a D1, D2, and 5-HT2A receptor antagonist with pKi values of 6.372, 7.88 and 7.619. Biriperone blocks amphetamine-induced hyperactivity and stereotypy in rodents. Biriperone blocks secondary conditioned avoidance responses in rodents. Biriperone can be used for the research of schizophrenia[1].
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Biriperone | Biriperone is a D1, D2, and 5-HT2A receptor antagonist with pKi values of 6.372, 7.88 and 7.619. Biriperone blocks amphetamine-induced hyperactivity and stereotypy in rodents. Biriperone blocks secondary conditioned avoidance responses in rodents. Biriperone can be used for the research of schizophrenia. | |||||||||||||||||||||
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- [1]. Chakrabarty R, et al. Rational design, synthesis and evaluation of (6aR( *),11bS( *))-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent. Bioorg Med Chem. 2007 Dec 1;15(23):7361-7. [Content Brief]
Keywords
