461443-59-4
461443-59-4
Chemical Structure
Aplaviroc
Synonym(s): AK 602; GSK 873140; GW 873140
- CAS No.: 461443-59-4
- Formula:C33H43N3O6
- Molecular Weight:577.71
IUPAC Name: 4-(4-(((R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro[5.5]undecan-9-yl)methyl)phenoxy)benzoic acid
InChIKey: GWNOTCOIYUNTQP-FQLXRVMXSA-N
SMILES: O=C(O)C1=CC=C(OC2=CC=C(CN(CC3)CCC3(N(CCCC)C([C@@H]([C@@H](C4CCCCC4)O)N5)=O)C5=O)C=C2)C=C1
Biological Activity: Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
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Aplaviroc | Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. | |||||||||||||||||||||
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Keywords
