480439-15-4
Chemical Structure
Fluorescein O-methacrylate
Synonym(s): Methacryloyloxy fluorescein
- CAS No.: 480439-15-4
- Formula:C24H16O6
- Molecular Weight:400.38
InChIKey: YMHPNLUYVDEYCI-UHFFFAOYSA-N
SMILES: O=C(C(C)=C)OC1=CC=C2C(OC3=CC(O)=CC=C3C24OC(C5=C4C=CC=C5)=O)=C1
Biological Activity: Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm)[1][2].
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Fluorescein O-methacrylate | 95.80% | Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm). | ||||||||||||||||||||
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- [1]. Alper Nese, et al. pH-Responsive Fluorescent Molecular Bottlebrushes Prepared by Atom Transfer Radical Polymerization. Macromolecules 2011, 44, 15, 5905-5910.
- [2]. Woo J, et al. Novel fluorescein polymer-based nanoparticles: facile and controllable one-pot synthesis, assembly, and immobilization of biomolecules for application in a highly sensitive biosensor. RSC Adv. 2020;10(5):2998-3004. Published 2020 Jan 16. [Content Brief]
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