489-33-8
Chemical Structure
Limocitrin
- CAS No.: 489-33-8
- Formula:C17H14O8
- Molecular Weight:346.29
IUPAC Name: 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-8-methoxy-4H-chromen-4-one
InChIKey: IBXCKSUZOFKGSB-UHFFFAOYSA-N
SMILES: O=C1C(O)=C(OC2=C(C(O)=CC(O)=C12)OC)C3=CC(OC)=C(C=C3)O
Biological Activity: Limocitrin is a flavonol glycoside. Limocitrin inhibits AKT phosphorylation and JNK phosphorylation, upregulates p38 phosphorylation, and inhibits ERK1/2 phosphorylation, thereby blocking MAPK signaling. Limocitrin induces Apoptosis through the mitochondrial pathway, death receptor-mediated signaling, Caspase activation, and G2/M cell cycle arrest. Limocitrin possesses anti-inflammatory and anticancer properties. Limocitrin can be used for research on oral squamous cell carcinoma and chronic myeloid leukemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Limocitrin | 99.58% | Limocitrin is a flavonol glycoside. Limocitrin inhibits AKT phosphorylation and JNK phosphorylation, upregulates p38 phosphorylation, and inhibits ERK1/2 phosphorylation, thereby blocking MAPK signaling. Limocitrin induces Apoptosis through the mitochondrial pathway, death receptor-mediated signaling, Caspase activation, and G2/M cell cycle arrest. Limocitrin possesses anti-inflammatory and anticancer properties. Limocitrin can be used for research on oral squamous cell carcinoma and chronic myeloid leukemia. | ||||||||||||||||||||
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References
- [1]. Velmurugan BK, et al. Limocitrin induced cellular death through ERK pathways in human oral squamous cell cancer. Scientific reports. 2025 May 22;15(1):17788.
- [2]. Hsieh MJ, et al. Limocitrin increases cytotoxicity of KHYG-1 cells against K562 cells by modulating MAPK pathway. Environmental toxicology. 2023 Dec;38(12):2939-2951.
