57343-54-1
57343-54-1
Chemical Structure
DQn-1
- CAS No.: 57343-54-1
- Formula:C16H14ClN5O2
- Molecular Weight:343.77
IUPAC Name: 4-(((2,4-diamino-5-chloroquinazolin-6-yl)methyl)amino)benzoic acid
InChIKey: OARHSEZBVKKLFI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(NCC2=CC=C3N=C(N)N=C(C3=C2Cl)N)C=C1)O
Biological Activity: DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1].
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DQn-1 | DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively. | |||||||||||||||||||||
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References
Keywords
