6011-39-8
Chemical Structure
Clemizole penicillin
- CAS No.: 6011-39-8
- Formula:C35H38ClN5O4S
- Molecular Weight:660.23
IUPAC Name: 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
InChIKey: GKPMEGXMKPQRTN-CBDIPHIASA-N
SMILES: C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(CC3=CC=CC=C3)=O)C2=O)(SC1(C)C)[H].C(N1C=2C(N=C1CN3CCCC3)=CC=CC2)C4=CC=C(Cl)C=C4
Biological Activity: Clemizole penicillin is a composite preparation containing two active components, Clemizole (HY-30234) and penicillin, with antihistamine, anti-inflammatory, and bactericidal activities. The Clemizole component of Clemizole penicillin targets the H1 receptor, CrtN, and TRPC5 calcium channel, while penicillin exerts antibacterial effects. The clemizole contained in Clemizole penicillin acts as a reversible competitive inhibitor of the TRPC5 calcium channel; it also competitively targets the CrtN enzyme of Staphylococcus aureus to block staphyloxanthin biosynthesis. Clemizole penicillin can be used in research on lobar pneumonia and syphilis[1][2][3][4][5].
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Clemizole penicillin | Clemizole penicillin is a composite preparation containing two active components, Clemizole (HY-30234) and penicillin, with antihistamine, anti-inflammatory, and bactericidal activities. The Clemizole component of Clemizole penicillin targets the H1 receptor, CrtN, and TRPC5 calcium channel, while penicillin exerts antibacterial effects. The clemizole contained in Clemizole penicillin acts as a reversible competitive inhibitor of the TRPC5 calcium channel; it also competitively targets the CrtN enzyme of Staphylococcus aureus to block staphyloxanthin biosynthesis. Clemizole penicillin can be used in research on lobar pneumonia and syphilis. | |||||||||||||||||||||
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- [1]. Yu H, et al. Clemizole inhibits CrtN-driven staphyloxanthin biosynthesis in Staphylococcus aureus to enhance host immune clearance. Communications biology. 2026 Feb 25;9(1):484. [Content Brief]
- [2]. Sutton DR, et al. One-day treatment for lobar pneumonia. Thorax. 1970 Mar;25(2):241-4.
- [3]. Jie LJ, et al. Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells. British journal of pharmacology. 2017 Feb;174(3):254-266. [Content Brief]
- [4]. Kumaş-Kulualp M, et al. Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin-induced nephrotoxicity in Spraque-Dawley rats. Journal of biochemical and molecular toxicology. 2023 Jul;37(7):e23372. [Content Brief]
- [5]. Spornraft-Ragaller P, et al. Response of HIV-infected patients with syphilis to therapy with penicillin or intravenous ceftriaxone. European journal of medical research. 2011 Feb 24;16(2):47-51. [Content Brief]
Keywords
