Clemizole penicillin
Clemizole penicillin is a composite preparation containing two active components, Clemizole (HY-30234) and penicillin, with antihistamine, anti-inflammatory, and bactericidal activities. The Clemizole component of Clemizole penicillin targets the H1 receptor, CrtN, and TRPC5 calcium channel, while penicillin exerts antibacterial effects. The clemizole contained in Clemizole penicillin acts as a reversible competitive inhibitor of the TRPC5 calcium channel; it also competitively targets the CrtN enzyme of Staphylococcus aureus to block staphyloxanthin biosynthesis. Clemizole penicillin can be used in research on lobar pneumonia and syphilis.
For research use only. We do not sell to patients.
- CAS No.: 6011-39-8
- Formula: C35H38ClN5O4S
- Molecular Weight:660.23
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Histamine Receptor Isoforms
More
Biological Activity
Clemizole penicillin produces stable serological improvement in active syphilis systems with concurrent HIV infection, and this long-acting intramuscular sustained-release composite preparation can be used in studies on the combined anti-allergic and anti-spirochete mechanisms related to syphilis[3][4][5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 6011-39-8
-
Molecular Weight 660.23
-
Formula C35H38ClN5O4S
-
SMILES
C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(CC3=CC=CC=C3)=O)C2=O)(SC1(C)C)[H].C(N1C=2C(N=C1CN3CCCC3)=CC=CC2)C4=CC=C(Cl)C=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yu H, et al. Clemizole inhibits CrtN-driven staphyloxanthin biosynthesis in Staphylococcus aureus to enhance host immune clearance. Communications biology. 2026 Feb 25;9(1):484. [Content Brief]
[2]. Sutton DR, et al. One-day treatment for lobar pneumonia. Thorax. 1970 Mar;25(2):241-4.
[3]. Jie LJ, et al. Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells. British journal of pharmacology. 2017 Feb;174(3):254-266. [Content Brief]
[4]. Kumaş-Kulualp M, et al. Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin-induced nephrotoxicity in Spraque-Dawley rats. Journal of biochemical and molecular toxicology. 2023 Jul;37(7):e23372. [Content Brief]
[5]. Spornraft-Ragaller P, et al. Response of HIV-infected patients with syphilis to therapy with penicillin or intravenous ceftriaxone. European journal of medical research. 2011 Feb 24;16(2):47-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Clemizole penicillin Related Classifications
HY-W754356 Related Classifications
Powered by Bioz