6018-28-6
6018-28-6
Chemical Structure
Arecaidine hydrochloride
- CAS No.: 6018-28-6
- Formula:C7H12ClNO2
- Molecular Weight:177.63
IUPAC Name: 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
InChIKey: PIVDNPNYIBGXPL-UHFFFAOYSA-N
SMILES: O=C(C1=CCCN(C)C1)O.[H]Cl
Biological Activity: Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].
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Arecaidine hydrochloride | 98.0% | Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake. | ||||||||||||||||||||
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Arecaidine hydrochloride (Standard) | ≥98% | Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake. | ||||||||||||||||||||
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References
- [1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22. [Content Brief]
- [2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90. [Content Brief]
