6116-75-2
![3-[(4-Aminobutyl)amino]propanenitrile Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-187138.gif "3-[(4-Aminobutyl)amino]propanenitrile Chemical Structure")
Chemical Structure
3-[(4-Aminobutyl)amino]propanenitrile
- CAS No.: 6116-75-2
- Formula:C10H13NO
- Molecular Weight:163.22
IUPAC Name: 2,3-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one
InChIKey: UORPHFZBCZEBJV-UHFFFAOYSA-N
SMILES: O=C1C2=C(NC(=C2C)C)CCC1
Biological Activity: 3-[(4-Aminobutyl) amino]propanenitrile is a polyamine analog and also a synthetic intermediate. 3-[(4-Aminobutyl) amino]propanenitrile exhibits no growth inhibitory activity against cancer cells in culture medium supplemented with calf serum containing bovine plasma amine oxidase. 3-[(4-Aminobutyl) amino]propanenitrile can be used to prepare N1-substituted spermidine derivatives required for boron neutron capture therapy and positron emission tomography tumor imaging[1][2].
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3-[(4-Aminobutyl)amino]propanenitrile | 3-[(4-Aminobutyl) amino]propanenitrile is a polyamine analog and also a synthetic intermediate. 3-[(4-Aminobutyl) amino]propanenitrile exhibits no growth inhibitory activity against cancer cells in culture medium supplemented with calf serum containing bovine plasma amine oxidase. 3-[(4-Aminobutyl) amino]propanenitrile can be used to prepare N1-substituted spermidine derivatives required for boron neutron capture therapy and positron emission tomography tumor imaging. | |||||||||||||||||||||
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- [1]. Israel M, et al. Synthesis of aminoethyl derivatives of alpha, omega-alkylenediamines and structure-activity relationships for the polyamine-bovine plasma amine oxidase system. J Med Chem. 1971 Nov;14(11):1042-7.
- [2]. Martin B, et al. N-Benzylpolyamines as vectors of boron and fluorine for cancer therapy and imaging: synthesis and biological evaluation. Journal of medicinal chemistry. 2001 Oct 25;44(22):3653-64.
