635724-55-9
Chemical Structure
Esreboxetine succinate
Synonym(s): PNU-165442G; (S,S)-Reboxetine succinate
- CAS No.: 635724-55-9
- Formula:C23H29NO7
- Molecular Weight:431.48
IUPAC Name: (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine succinate
InChIKey: YXZTUOWIYOESGT-HLRBRJAUSA-N
SMILES: OC(CCC(O)=O)=O.CCOC(C=CC=C1)=C1O[C@H]([C@]2([H])CNCCO2)C3=CC=CC=C3
Biological Activity: Esreboxetine succinate (PNU-165442G; (S,S)-Reboxetine succinate) is a selective norepinephrine transporter (NET) inhibitor, with a pIC50 of 9.6 and a pKi of 9.2 in rats, and it can cross the blood-brain barrier. Esreboxetine succinate increases urethral closure pressure and urethral resistance in rats. Esreboxetine succinate is applicable to research related to inflammatory pain and stress urinary incontinence[1][2].
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Esreboxetine succinate | Esreboxetine succinate (PNU-165442G; (S,S)-Reboxetine succinate) is a selective norepinephrine transporter (NET) inhibitor, with a pIC50 of 9.6 and a pKi of 9.2 in rats, and it can cross the blood-brain barrier. Esreboxetine succinate increases urethral closure pressure and urethral resistance in rats. Esreboxetine succinate is applicable to research related to inflammatory pain and stress urinary incontinence. | |||||||||||||||||||||
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References
- [1]. Shen F, et al. Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model. PloS one. 2013;8(9):e74891.
- [2]. Fujimori I, et al. Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor. Bioorg Med Chem. 2015 Aug 1;23(15):5000-5014. [Content Brief]
