639507-03-2
639507-03-2
Chemical Structure
CFM-5
- CAS No.: 639507-03-2
- Formula:C23H18BrN3OS
- Molecular Weight:464.38
IUPAC Name: 5-bromo-1-phenethyl-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one
InChIKey: XNQKFLVXBADQOZ-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(C13SC(C4=CC=CC=C4)=NN3)C=C(C=C2)Br)CCC5=CC=CC=C5
Biological Activity: CFM-5 inhibits CARP-1/CCAR1-APC-2 interaction with an IC50 value of 0.75 μM. CFM-5 inhibits medulloblastoma (MB) cell proliferation and induces apoptosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CFM-5 | 99.48% | CFM-5 inhibits CARP-1/CCAR1-APC-2 interaction with an IC50 value of 0.75 μM. CFM-5 inhibits medulloblastoma (MB) cell proliferation and induces apoptosis. | ||||||||||||||||||||
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References
- [1]. Abdelkader E Ashour, et al. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS One. 2013 Jun 24;8(6):e66733. [Content Brief]
- [2]. Magesh Muthu, et al. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget. 2015 Mar 30;6(9):6499-510. [Content Brief]
Keywords
