652973-93-8
Chemical Structure
Calhex 231
- CAS 番号: 652973-93-8
- Formula:C25H27ClN2O
- Molecular Weight:406.95
IUPAC Name: 4-chloro-N-((1S,2S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)cyclohexyl)benzamide
InChIKey: YTFUQWWKTIWYEY-CQLNOVPUSA-N
SMILES: O=C(N[C@@H]1[C@@H](N[C@@H](C2=C3C=CC=CC3=CC=C2)C)CCCC1)C4=CC=C(Cl)C=C4
Biological Activity: Calhex 231 is a potent negative allosteric modulator that blocks (IC50 = 0.39 μM) increases in [3H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca2+-sensing receptor. Calhex 231 can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM)[1].
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Calhex 231 | Calhex 231 is a potent negative allosteric modulator that blocks (IC50 = 0.39 μM) increases in [3H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca2+-sensing receptor. Calhex 231 can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM). | |||||||||||||||||||||
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Keywords
