663933-94-6
Chemical Structure
pPB peptide
- CAS No.: 663933-94-6
- Formula:C35H60N12O13S2
- Molecular Weight:921.05
InChIKey: RRMCXKSQKFWQIJ-SOEWCGCPSA-N
SMILES: O=C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC1)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H]1N
Biological Activity: pPB peptide is a cyclic peptide targeting platelet-derived growth factor receptor β (PDGFRβ). Derived from natural platelet-derived growth factor (PDGF), pPB peptide contains arginine and isoleucine as key receptor-binding residues. pPB peptide specifically binds to PDGFRβ, which is highly expressed on the surface of activated hepatic stellate cells (HSC). pPB peptide can be used in studies related to liver fibrosis, liver cirrhosis, and tumor-specific drug delivery[1][2][3][4].
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pPB peptide | pPB peptide is a cyclic peptide targeting platelet-derived growth factor receptor β (PDGFRβ). Derived from natural platelet-derived growth factor (PDGF), pPB peptide contains arginine and isoleucine as key receptor-binding residues. pPB peptide specifically binds to PDGFRβ, which is highly expressed on the surface of activated hepatic stellate cells (HSC). pPB peptide can be used in studies related to liver fibrosis, liver cirrhosis, and tumor-specific drug delivery. | |||||||||||||||||||||
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- [1]. Wang Y, et al. Remodeling liver microenvironment by L-arginine loaded hollow polydopamine nanoparticles for liver cirrhosis treatment. Biomaterials. 2023 Apr;295:122028.
- [2]. Zhang J, et al. Liver-Targeted siRNA Lipid Nanoparticles Treat Hepatic Cirrhosis by Dual Antifibrotic and Anti-inflammatory Activities. ACS nano. 2020 May 26;14(5):6305-6322.
- [3]. Yuan M, et al. Modification of MSCs with aHSCs-targeting peptide pPB for enhanced therapeutic efficacy in liver fibrosis. Biomaterials. 2025 Oct;321:123295.
- [4]. Bansal R, et al. Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice. Hepatology (Baltimore, Md.). 2011 Aug;54(2):586-96. [Content Brief]
Keywords
