671225-39-1
Chemical Structure
Cardiogenol C
- CAS No.: 671225-39-1
- Formula:C13H16N4O2
- Molecular Weight:260.29
IUPAC Name: 2-((2-((4-methoxyphenyl)amino)pyrimidin-4-yl)amino)ethan-1-ol
InChIKey: LKBSMPFEKIBRGC-UHFFFAOYSA-N
SMILES: COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1
Biological Activity: Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM)[1]. Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].
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Cardiogenol C | Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM). Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models. | |||||||||||||||||||||
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- [1]. Wu X, et al. Small molecules that induce cardiomyogenesis in embryonic stem cells.J Am Chem Soc. 2004 Feb 18;126(6):1590-1. [Content Brief]
- [2]. Mike AK, et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33(1):205-21. [Content Brief]
Keywords
