1. Stem Cell/Wnt
  2. β-catenin
    Wnt
  3. Cardiogenol C

Cardiogenol C 

Cat. No.: HY-12319
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Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM). Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models.

For research use only. We do not sell to patients.

Cardiogenol C Chemical Structure

Cardiogenol C Chemical Structure

CAS No. : 671225-39-1

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Description

Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM)[1]. Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].

IC50 & Target

EC50: 100 nM (differentiation of ESCs into cardiomyocytes)[1]

In Vitro

Cardiogenol C (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF, nppa) in P19 cells when it compares to untreated control cells[1].
Cardiogenol C (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells[2].
Cardiogenol C (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells[2].
Cardiogenol C (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells[2].

RT-PCR[2]

Cell Line: C2C12 cells
Concentration: 0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM
Incubation Time: 7 days
Result: Increases ANF and NKX2.5 mRNA level as a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: C2C12 cells
Concentration: 0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM
Incubation Time: 7 days
Result: Increased cardiac Nav1.5 sodium channel protein levels.

Cell Proliferation Assay[2]

Cell Line: C2C12 cells
Concentration: 0.01 μM; 0.1 μM; 1 μM
Incubation Time: 7 days
Result: Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.
Molecular Weight

260.29

Formula

C₁₃H₁₆N₄O₂

CAS No.

671225-39-1

SMILES

COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Cardiogenol Cβ-cateninWntBeta cateninCardiomyogenicembryonicstemcellstransplantation,?progenitorplasticityescpyrimidineMHCInhibitorinhibitorinhibit

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