1. Stem Cell/Wnt
  2. β-catenin
    Wnt

Cardiogenol C hydrochloride 

Cat. No.: HY-12319A Purity: 96.22%
Handling Instructions

Cardiogenol C hydrochloride is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).

For research use only. We do not sell to patients.

Cardiogenol C hydrochloride Chemical Structure

Cardiogenol C hydrochloride Chemical Structure

CAS No. : 1049741-55-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Cardiogenol C hydrochloride is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). IC50 value: 100 nM (EC50) Target: in vitro: Cardiogenol C hydrochloride is a cardiomyogenesis inducer in embryonic stem cells. Cardiogenol C induces the differentiation of myosin heavy chain-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 μM; about 90% of embryonic stem cells treated with 0.25 μM of Cardiogenol C express the cardiac muscle cell specific transcription factors GATA-4, MEF2, and Nkx2.5 and display the characteristic beating behavior of differentiated cardiomyocytes. Cardiogenol C (a diaminopyrimidine) induces cardiac differentiation in P19 and in P19Cl6 cells. [1] Cardiogenol C could activate Wnt/β-catenin signaling to induce cardiogenesis. Cardiogenol C-treatment significantly decreased HBPCs proliferation. Cardiogenol C was able to induce HBPCs to transdifferentiate into cardiomyocyte-like cells.[2]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 59 mg/mL (198.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3698 mL 16.8492 mL 33.6984 mL
5 mM 0.6740 mL 3.3698 mL 6.7397 mL
10 mM 0.3370 mL 1.6849 mL 3.3698 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

296.75

Formula

C₁₃H₁₇ClN₄O₂

CAS No.

1049741-55-0

SMILES

[H]Cl.COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Cardiogenol C hydrochloride
Cat. No.:
HY-12319A
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Cardiogenol C hydrochloride

Cat. No.: HY-12319A