689293-68-3
Chemical Structure
Ceftolozane
Synonym(s): CXA-101 free base; FR264205 free base
- CAS No.: 689293-68-3
- Formula:C23H30N12O8S2
- Molecular Weight:666.69
IUPAC Name: (6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChIKey: JHFNIHVVXRKLEF-DCZLAGFPSA-N
SMILES: CN1[N+](CC(CS[C@]2([H])[C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N2C3=O)=CC(NC(NCCN)=O)=C1N
Biological Activity: Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L[1].
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Ceftolozane | Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L. | |||||||||||||||||||||
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Ceftolozane-15N2,d4 TFA | Ceftolozane-15N2,d4 (CXA-101-15N2,d4) TFA is the 15N- and deuterium-labeled Ceftolozane TFA (HY-106257A). Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections. Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer. | |||||||||||||||||||||
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- [1]. Craig WA, et al., In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum β-lactamases, in the thighs of neutropenic mice. Antimicrob Agents Chemother. 2013 Apr;57(4):1577-82. [Content Brief]
Keywords
