689293-68-3
Chemical Structure
Ceftolozane
Synonym(s): CXA-101 free base; FR264205 free base
- CAS No.: 689293-68-3
- Formula:C23H30N12O8S2
- Molecular Weight:666.69
IUPAC Name: (6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChIKey: JHFNIHVVXRKLEF-DCZLAGFPSA-N
SMILES: CN1[N+](CC(CS[C@]2([H])[C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N2C3=O)=CC(NC(NCCN)=O)=C1N
Biological Activity: Ceftolozane is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane can be used in studies related to bacterial infections[1][2][3][4].
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Ceftolozane | Ceftolozane is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane can be used in studies related to bacterial infections. | |||||||||||||||||||||
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Ceftolozane-15N2,d4 TFA | Ceftolozane-15N2,d4 (CXA-101-15N2,d4) TFA is the 15N- and deuterium-labeled Ceftolozane TFA (HY-106257A). Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections. Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer. | |||||||||||||||||||||
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References
- [1]. Gu, J.-Q., et al. (2016, February 25). Salt forms of ceftolozane. World Intellectual Property Organization. WO 2016/028670 A1.
- [2]. Martens-Lobenhoffer J, et al. Stability of ceftolozane in human plasma and dried blood spots: Implications for transport and storage. Journal of pharmacological and toxicological methods. 2020;103:106692.
- [3]. Yu B, et al. Safety, Tolerability, and Pharmacokinetics of 3 g of Ceftolozane/Tazobactam in Healthy Adults: A Randomized, Placebo-Controlled, Multiple-Dose Study. Clinical pharmacology in drug development. 2018 May;7(4):382-391. [Content Brief]
- [4]. Knappe D, et al. Oncocin Onc72 is efficacious against antibiotic-susceptible Klebsiella pneumoniae ATCC 43816 in a murine thigh infection model. Biopolymers. 2015 Nov;104(6):707-11.
