69429-85-2
Chemical Structure
Cilobamine methanesulfonate
- CAS No.: 69429-85-2
- Formula:C18H27Cl2NO4S
- Molecular Weight:424.38
InChIKey: VALAKNBZUXDQCX-UHFFFAOYSA-N
SMILES: O=S(O)(C)=O.ClC1=CC=C(C2(C(C3CCC2CC3)NC(C)C)O)C=C1Cl
Biological Activity: Cilobamine methanesulfonate is an orally active antidepressant and a dopamine/norepinephrine reuptake inhibitor. Cilobamine methanesulfonate increases the levels of Aniline hydroxylase and cytochrome P-450 in rat liver. Cilobamine methanesulfonate promotes hypertrophy of the smooth endoplasmic reticulum in rat liver hepatocytes, increases relative liver weight and recoverable microsomal protein. Cilobamine methanesulfonate produces stimulant and anxiogenic effects, and does not inhibit monoamine oxidase. Cilobamine methanesulfonate can be used in the research of depression[1][2].
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Cilobamine methanesulfonate | Cilobamine methanesulfonate is an orally active antidepressant and a dopamine/norepinephrine reuptake inhibitor. Cilobamine methanesulfonate increases the levels of Aniline hydroxylase and cytochrome P-450 in rat liver. Cilobamine methanesulfonate promotes hypertrophy of the smooth endoplasmic reticulum in rat liver hepatocytes, increases relative liver weight and recoverable microsomal protein. Cilobamine methanesulfonate produces stimulant and anxiogenic effects, and does not inhibit monoamine oxidase. Cilobamine methanesulfonate can be used in the research of depression. | |||||||||||||||||||||
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- [1]. Leeson GA, et al. Dose related induction of the drug metabolizing enzymes of rat liver by cilobamine. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 1):261-9. [Content Brief]
- [2]. Wager S, et al. Cilobamine in the treatment of atypical depression[J]. Human Psychopharmacology: Clinical and Experimental, 1988, 3(3): 201-205.
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