726174-00-1
726174-00-1
Chemical Structure
A-381393
- CAS 番号: 726174-00-1
- Formula:C20H24N4
- Molecular Weight:320.43
IUPAC Name: 2-((4-(3,4-dimethylphenyl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole
InChIKey: SAQMCVDGOIRQTC-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1C)N2CCN(CC2)CC3=NC4=CC=CC=C4N3
Biological Activity: A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1].
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A-381393 | 99.92% | A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM). | ||||||||||||||||||||
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References
Keywords
