784211-09-2
Chemical Structure
RGB-286147
- CAS No.: 784211-09-2
- Formula:C23H22Cl2N4O3
- Molecular Weight:473.35
IUPAC Name: 1-(2,6-dichlorophenyl)-6-(4-(2-hydroxyethoxy)benzyl)-3-isopropyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
InChIKey: RSQPNXBTPUXMQN-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C3=C(Cl)C=CC=C3Cl)N=C2C(C)C)N=C(CC4=CC=C(OCCO)C=C4)N1
Biological Activity: RGB-286147 is a selective and ATP-competitive CDK and CDK-related kinases (CRK) inhibitor with IC50 values ranging from 9-839 nM. RGB-286147 shows less active against other non-CDK/CRK kinases. RGB-286147 induces cell apoptosis, and exhibits anti-tumor activity[1].
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RGB-286147 | 98.60% | RGB-286147 is a selective and ATP-competitive CDK and CDK-related kinases (CRK) inhibitor with IC50 values ranging from 9-839 nM. RGB-286147 shows less active against other non-CDK/CRK kinases. RGB-286147 induces cell apoptosis, and exhibits anti-tumor activity. | ||||||||||||||||||||
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Keywords
