802904-66-1
802904-66-1
Chemical Structure
AZD1981
- CAS No.: 802904-66-1
- Formula:C19H17ClN2O3S
- Molecular Weight:388.87
IUPAC Name: 2-(4-acetamido-3-((4-chlorophenyl)thio)-2-methyl-1H-indol-1-yl)acetic acid
InChIKey: JWYIGNODXSRKGP-UHFFFAOYSA-N
SMILES: O=C(O)CN1C(C)=C(SC2=CC=C(Cl)C=C2)C3=C1C=CC=C3NC(C)=O
Biological Activity: AZD1981 is the antagonist for GPR44 (also known also PTGDR2, DP2 or CRTh). AZD1981 blocks the binding of PGD2 to CRTH2. AZD1981 exhibits immunomodulatory effects and can be used in research of chronic spontaneous urticaria[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZD1981 | 99.80% | AZD1981 is the antagonist for GPR44 (also known also PTGDR2, DP2 or CRTh). AZD1981 blocks the binding of PGD2 to CRTH2. AZD1981 exhibits immunomodulatory effects and can be used in research of chronic spontaneous urticaria. | ||||||||||||||||||||
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AZD1981 (Standard) | ≥98% | AZD1981 (Standard) is the analytical standard of AZD1981. This product is intended for research and analytical applications. AZD1981 is the antagonist for GPR44 (also known also PTGDR2, DP2 or CRTh). AZD1981 blocks the binding of PGD2 to CRTH2. AZD1981 exhibits immunomodulatory effects and can be used in research of chronic spontaneous urticaria. | ||||||||||||||||||||
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References
- [1]. Hu S, et al., PGD2 displays distinct effects in diffuse large B-cell lymphoma depending on different concentrations. Cell Death Discov. 2023 Feb 1;9(1):39. [Content Brief]
- [2]. Oliver ET, et al., Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria. Int Arch Allergy Immunol. 2019;179(1):21-30. [Content Brief]
Keywords
