848667-56-1
Chemical Structure
(±)2-(14,15-Epoxyeicosatrienoyl) glycerol
Synonym(s): (±)2-14,15-EG
- CAS No.: 848667-56-1
- Formula:C23H38O5
- Molecular Weight:394.54
InChIKey: LPMVKZXODWQHGJ-ILYOTBPNSA-N
SMILES: OCC(CO)OC(CCC/C=C\C/C=C\C/C=C\CC1C(O1)CCCCC)=O
Biological Activity: (±)2-(14,15-Epoxyeicosatrienoyl) glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol activates the metalloprotease ADAM17, which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway[1].
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(±)2-(14,15-Epoxyeicosatrienoyl) glycerol | (±)2-(14,15-Epoxyeicosatrienoyl) glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol activates the metalloprotease ADAM17, which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway. | |||||||||||||||||||||
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