849215-53-8
Chemical Structure
Aristoforin
- CAS No.: 849215-53-8
- Formula:C37H54O6
- Molecular Weight:594.82
IUPAC Name: 2-(((1R,5R,6R,7S)-5-isobutyryl-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-4,9-dioxobicyclo[3.3.1]non-2-en-2-yl)oxy)acetic acid
InChIKey: VPLDQWWNHPHRIL-DZLQXDJLSA-N
SMILES: CC(C)C([C@@]12[C@@](C)([C@H](C[C@@](C1=O)(C(OCC(O)=O)=C(C2=O)C/C=C(C)\C)C/C=C(C)\C)C/C=C(C)\C)CC/C=C(C)/C)=O
Biological Activity: Aristoforin, a hypericin derivative, inhibits the activities of SIRT1 and SIRT2. Aristoforin induces G1 phase cell cycle arrest, scavenges hydroxyl free radicals, and exhibits protective activity against Fe2+-induced DNA breakage. Aristoforin can be used in studies related to breast cancer and colon adenocarcinoma[1][2][3][4].
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Aristoforin | Aristoforin, a hypericin derivative, inhibits the activities of SIRT1 and SIRT2. Aristoforin induces G1 phase cell cycle arrest, scavenges hydroxyl free radicals, and exhibits protective activity against Fe2+-induced DNA breakage. Aristoforin can be used in studies related to breast cancer and colon adenocarcinoma. | |||||||||||||||||||||
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- [1]. Rothley M, et al. Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo. Int J Cancer. 2009;125(1):34-42. [Content Brief]
- [2]. Šemeláková M, et al. Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. Biomed Pharmacother. 2016;81:38-47. [Content Brief]
- [3]. Ševčovičová A, et al. DNA-protective activities of hyperforin and aristoforin. Toxicol In Vitro. 2015;29(3):631-637. [Content Brief]
- [4]. Šemeláková M, et al. The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells. J Photochem Photobiol B. 2012;117:115-125. [Content Brief]
Keywords
