851510-67-3
Chemical Structure
ASP4000 free base
- CAS No.: 851510-67-3
- Formula:C12H17N3O2
- Molecular Weight:235.29
IUPAC Name: (S)-1-((1R,3S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-3-carbonyl)pyrrolidine-2-carbonitrile
InChIKey: FVTNKOGXEQXHHE-DAWVFNFOSA-N
SMILES: C(=O)([C@@H]1[C@]2(C[C@@](N1)([C@H](O)C2)[H])[H])N3[C@H](C#N)CCC3
Biological Activity: ASP4000 free base is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 free base reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 free base can be used in studies related to type 2 diabetes[1].
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ASP4000 free base | ASP4000 free base is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 free base reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 free base can be used in studies related to type 2 diabetes. | |||||||||||||||||||||
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