868698-49-1
868698-49-1
Chemical Structure
(R)-(-)-α-Methylhistamine dihydrobromide
- CAS No.: 868698-49-1
- Formula:C6H13Br2N3
- Molecular Weight:287.00
IUPAC Name: (R)-1-(1H-imidazol-5-yl)propan-2-amine dihydrobromide
InChIKey: RWHNAAABSGVRDT-ZJIMSODOSA-N
SMILES: C[C@@H](N)CC1=CN=CN1.Br.Br
Biological Activity: (R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM[1][2]. (R)-(-)-α-Methylhistamine dihydrobromide can enhance memory retention, attenuates memory impairment in rats[3][4][5].
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(R)-(-)-α-Methylhistamine dihydrobromide | (R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can enhance memory retention, attenuates memory impairment in rats. | |||||||||||||||||||||
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References
- [1]. Arrang JM, et al. Highly potent and selective ligands for histamine H3-receptors. Nature. 1987 May 14-20;327(6118):117-23. [Content Brief]
- [2]. Mohammad Shahid, et al. Histamine, Histamine Receptors, and their Role in Immunomodulation: An Updated Systematic Review. The Open Immunology Journal, 2009, 2, 9-41.
- [3]. Oishi R, et al. Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamideon histamine metabolism in the mouse and rat brain. J Neurochem. 1989 May;52(5):1388-92. [Content Brief]
- [4]. Yamasaki S, et al. The disposition of (R)-alpha-methylhistamine, a histamine H3-receptor agonist, in rats. J Pharm Pharmacol. 1994 May;46(5):371-4. [Content Brief]
- [5]. Li WW, et al. (R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats. CNS Neurosci Ther. 2014 Sep;20(9):851-9. [Content Brief]
