88068-72-8
Chemical Structure
SGB-1534 hydrochloride
- CAS 番号: 88068-72-8
- Formula:C21H25ClN4O3
- Molecular Weight:416.90
IUPAC Name: 3-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione hydrochloride
InChIKey: NPNDIKQZGVCHMQ-UHFFFAOYSA-N
SMILES: O=C(N1CCN2CCN(C3=C(C=CC=C3)OC)CC2)C4=CC=CC=C4NC1=O.Cl
Biological Activity: SGB-1534 hydrochloride is an orally active, selective and competitive antagonist of the alpha 1-adrenoceptor and the 5-HT2 receptor. SGB-1534 hydrochloride can inhibit vasoconstriction and lower blood pressure. SGB-1534 hydrochloride can be used for the research of cardiovascular disease, such as hypertension[1][2].
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SGB-1534 hydrochloride | SGB-1534 hydrochloride is an orally active, selective and competitive antagonist of the alpha 1-adrenoceptor and the 5-HT2 receptor. SGB-1534 hydrochloride can inhibit vasoconstriction and lower blood pressure. SGB-1534 hydrochloride can be used for the research of cardiovascular disease, such as hypertension. | |||||||||||||||||||||
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- [1]. Aono J, et al. Mechanism of the hypotensive effect of a novel phenylpiperazine derivative, SGB-1534: antagonism at alpha 1-adrenergic and 5-HT2 receptors. Arch Int Pharmacodyn Ther. 1985 Sep;277(1):126-39. [Content Brief]
- [2]. Nabata H, et al. Antihypertensive effects of a novel phenylpiperazine derivative, SGB-1534, on several hypertensive models of rats. Arch Int Pharmacodyn Ther. 1985 Sep;277(1):104-18. [Content Brief]
Keywords
