88475-69-8
Chemical Structure
(Rac)-Beraprost sodium
Synonym(s): (Rac)-TRK-100; (Rac)-ML 1129 sodium
- CAS No.: 88475-69-8
- Formula:C24H29NaO5
- Molecular Weight:420.47
IUPAC Name: (E)-4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoic acid, sodium salt
InChIKey: LJCCZMFYFWMMDN-UEIGIMKUSA-N
SMILES: O=C(CCCC1=CC=CC2=C1OC3CC(C(C23)/C=C/C(C(CC#CC)C)O)O)O[Na]
Biological Activity: (Rac)-Beraprost ((Rac)-ML 1129) sodium is a racemic isomer of Beraprost sodium (HY-13569A). Beraprost sodium is an orally active prostacyclin analog that inhibits the release of Ca2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost sodium has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(Rac)-Beraprost sodium | 99.0% | (Rac)-Beraprost ((Rac)-ML 1129) sodium is a racemic isomer of Beraprost sodium (HY-13569A). Beraprost sodium is an orally active prostacyclin analog that inhibits the release of Ca2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost sodium has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis. | ||||||||||||||||||||
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- [1]. Li S, et al. Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels. J Mol Med (Berl). 2019 Jun;97(6):777-791. [Content Brief]
- [2]. Yan P, et al. Clinical efficacy and safety of beraprost sodium in the treatment of nephrotic syndrome: A meta-analysis. Medicine (Baltimore). 2023 Oct 20;102(42):e34958. [Content Brief]
Keywords
