888958-27-8
Chemical Structure
SARS-CoV-IN-3
- CAS No.: 888958-27-8
- Formula:C25H20ClFeN3O
- Molecular Weight:469.74
InChIKey: QFUCUWLTDSJBPM-UHFFFAOYSA-N
SMILES: CCN(CCO)CC12=C3[Fe+2]145678(C9=C43)([C-]%10C5=C6C7=C8%10)[C-]29CNC%11=CC=NC%12=C%11C=CC(Cl)=C%12
Biological Activity: SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells[1].
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SARS-CoV-IN-3 | 99.36% | SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells. | ||||||||||||||||||||
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Keywords
