9013-53-0
Chemical Structure
Micrococcal nuclease
- CAS No.: 9013-53-0
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Micrococcal nuclease]
Biological Activity: Micrococcal nuclease is a secreted nuclease from Staphylococcus aureus. It digests single-stranded and double-stranded DNA (ssDNA and dsDNA) as well as RNA, cleaves oligonucleotide linkers with T-T sites, and cuts neutrophil extracellular traps and biofilm extracellular DNA into mononucleotides and dinucleotides. Micrococcal nuclease stimulates the formation of Staphylococcus aureus biofilms and mediates immune evasion. It triggers on-demand release of antibiotics from hydrogel coatings, prolongs the formation of neutrophil extracellular traps, and promotes the dissemination and survival of MRSA during infection. Micrococcal nuclease is applicable to research and characterization related to Staphylococcus aureus infection[1][2][3].
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Micrococcal nuclease | Micrococcal nuclease is a secreted nuclease from Staphylococcus aureus. It digests single-stranded and double-stranded DNA (ssDNA and dsDNA) as well as RNA, cleaves oligonucleotide linkers with T-T sites, and cuts neutrophil extracellular traps and biofilm extracellular DNA into mononucleotides and dinucleotides. Micrococcal nuclease stimulates the formation of Staphylococcus aureus biofilms and mediates immune evasion. It triggers on-demand release of antibiotics from hydrogel coatings, prolongs the formation of neutrophil extracellular traps, and promotes the dissemination and survival of MRSA during infection. Micrococcal nuclease is applicable to research and characterization related to Staphylococcus aureus infection. | |||||||||||||||||||||
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- [1]. Kaplan JB, et al. Micrococcal nuclease regulates biofilm formation and dispersal in methicillin-resistant Staphylococcus aureus USA300. mSphere. 2024 May 29;9(5):e0012624.
- [2]. Skelly JD, et al. Modulating Micrococcal Nuclease-Triggered Antibiotic Releases for One-Stage Revisions of Staphylococcus aureus-Infected Prostheses. ACS Infect Dis. 2026 Apr 10;12(4):1434-1447.
- [3]. Forson AM, et al. Micrococcal Nuclease stimulates Staphylococcus aureus Biofilm Formation in a Murine Implant Infection Model. Front Cell Infect Microbiol. 2022 Jan 17;11:799845.
Keywords
