903899-13-8
903899-13-8
Chemical Structure
6-Hydroxypyridin-3-ylboronic acid
- CAS No.: 903899-13-8
- Formula:C5H6BNO3
- Molecular Weight:138.92
IUPAC Name: (6-oxo-1,6-dihydropyridin-3-yl)boronic acid
InChIKey: YUOLAYZNDYRBEZ-UHFFFAOYSA-N
SMILES: OB(C1=CC=C(O)N=C1)O
Biological Activity: 6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors[1][2].
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6-Hydroxypyridin-3-ylboronic acid | 6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors. | |||||||||||||||||||||
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References
- [1]. Hendricks RT, et al. 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase. Bioorg Med Chem Lett. 2009 Jan 15;19(2):410-4. [Content Brief]
- [2]. Verheijen JC, et al. Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. [Content Brief]
Keywords
