909708-65-2
Chemical Structure
Liguzinediol
- CAS No.: 909708-65-2
- Formula:C8H12N2O2
- Molecular Weight:168.20
IUPAC Name: (3,6-dimethylpyrazine-2,5-diyl)dimethanol
InChIKey: DLCVYRQRINMKBM-UHFFFAOYSA-N
SMILES: OCC1=NC(=C(N=C1C)CO)C
Biological Activity: Liguzinediol is a protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor that enhances the activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a). Liguzinediol reduces the dephosphorylation level of phospholamban and increases the phosphorylation levels of phospholamban at serine-16 and threonine-17 sites. Liguzinediol exerts positive inotropic effects in rat hearts both in vivo and in vitro, and reverses caffeine-induced decrease in myocardial contractility in isolated rat hearts. Liguzinediol can be used for the research of heart failure[1].
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Liguzinediol | Liguzinediol is a protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor that enhances the activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a). Liguzinediol reduces the dephosphorylation level of phospholamban and increases the phosphorylation levels of phospholamban at serine-16 and threonine-17 sites. Liguzinediol exerts positive inotropic effects in rat hearts both in vivo and in vitro, and reverses caffeine-induced decrease in myocardial contractility in isolated rat hearts. Liguzinediol can be used for the research of heart failure. | |||||||||||||||||||||
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Keywords
