915407-80-6
Chemical Structure
GS-9160
- CAS No.: 915407-80-6
- Formula:C20H18FN3O4S
- Molecular Weight:415.44
IUPAC Name: N-(7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl)-N-methylmethanesulfonamide
InChIKey: RJWBOLLTMJMYNV-UHFFFAOYSA-N
SMILES: O=C1C=2C(O)=C3N=CC=CC3=C(C2CN1CC4=CC=C(F)C=C4)N(C)S(=O)(=O)C
Biological Activity: GS-9160 is a HIV-1 integrase strand transfer inhibitor with an IC50 of 28 nM. GS-9160 elevates the level of HIV-1 double long terminal repeat circles and reduces integration junctions. GS-9160 exhibits selective antiviral activity against HIV-1 in cells. GS-9160 can select for integrase mutants E92V and L74M, and shows synergistic activity with other HIV-1 inhibitors. GS-9160 can be used in studies related to HIV-1 infection[1][2][3].
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GS-9160 | GS-9160 is a HIV-1 integrase strand transfer inhibitor with an IC50 of 28 nM. GS-9160 elevates the level of HIV-1 double long terminal repeat circles and reduces integration junctions. GS-9160 exhibits selective antiviral activity against HIV-1 in cells. GS-9160 can select for integrase mutants E92V and L74M, and shows synergistic activity with other HIV-1 inhibitors. GS-9160 can be used in studies related to HIV-1 infection. | |||||||||||||||||||||
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- [1]. Jones GS, et al. Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase. Antimicrobial agents and chemotherapy. 2009 Mar;53(3):1194-203. [Content Brief]
- [2]. Choi E, et al. Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase. Future Sci OA. 2018 Sep 6;4(9):FSO338. [Content Brief]
- [3]. Alian A, et al. Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proceedings of the National Academy of Sciences of the United States of America. 2009 May 19;106(20):8192-7. [Content Brief]
Keywords
