916484-16-7
916484-16-7
Chemical Structure
J-30
- CAS No.: 916484-16-7
- Formula:C21H19N3O4S
- Molecular Weight:409.46
IUPAC Name: N-(1-((4-methoxyphenyl)sulfonyl)indolin-7-yl)isonicotinamide
InChIKey: QGWOKAXBIMWTNE-UHFFFAOYSA-N
SMILES: O=C(C1=CC=NC=C1)NC2=CC=CC3=C2N(CC3)S(=O)(C4=CC=C(C=C4)OC)=O
Biological Activity: J-30 is an orally active and potent tubulin inhibitor (IC50=15-20 nM). J-30 disrupts microtubule polymerization and induces G2/M phase arrest. J-30 is promising for research of solid tumors (e.g., gastric, oral)[1].
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J-30 | J-30 is an orally active and potent tubulin inhibitor (IC50=15-20 nM). J-30 disrupts microtubule polymerization and induces G2/M phase arrest. J-30 is promising for research of solid tumors (e.g., gastric, oral). | |||||||||||||||||||||
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References
- [1]. Liou JP, et al. A novel oral indoline-sulfonamide agent, N-[1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule. J Pharmacol Exp Ther. 2007 Oct;323(1):398-405. [Content Brief]
Keywords
