J-30
J-30 is an orally active and potent tubulin inhibitor (IC50=15-20 nM). J-30 disrupts microtubule polymerization and induces G2/M phase arrest. J-30 is promising for research of solid tumors (e.g., gastric, oral).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 916484-16-7
- Formel: C21H19N3O4S
- Molecular Weight:409.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
8.6 nM
Compound: 15, J-30
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Cytotoxicity against human HT29 cell line by methylene blue dye assay
Cytotoxicity against human HT29 cell line by methylene blue dye assay
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[PMID: 17154496] |
| KB | IC50 |
8.9 nM
Compound: 15, J-30
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Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay
Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay
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[PMID: 17154496] |
| KB | IC50 |
9.6 nM
Compound: 15, J-30
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Cytotoxicity against human KB cell line by methylene blue dye assay
Cytotoxicity against human KB cell line by methylene blue dye assay
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[PMID: 17154496] |
| MKN-45 | IC50 |
8.8 nM
Compound: 15, J-30
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Cytotoxicity against human MKN45 cell line by methylene blue dye assay
Cytotoxicity against human MKN45 cell line by methylene blue dye assay
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[PMID: 17154496] |
| NCI-H460 | IC50 |
9.4 nM
Compound: 15, J-30
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Cytotoxicity against human H460 cell line by methylene blue dye assay
Cytotoxicity against human H460 cell line by methylene blue dye assay
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[PMID: 17154496] |
| TSGH 9201 | IC50 |
10.8 nM
Compound: 15, J-30
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Cytotoxicity against human TSGH cell line by methylene blue dye assay
Cytotoxicity against human TSGH cell line by methylene blue dye assay
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[PMID: 17154496] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 916484-16-7
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Molecular Weight 409.46
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Formel C21H19N3O4S
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SMILES
O=C(C1=CC=NC=C1)NC2=CC=CC3=C2N(CC3)S(=O)(C4=CC=C(C=C4)OC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Liou JP, et al. A novel oral indoline-sulfonamide agent, N-[1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule. J Pharmacol Exp Ther. 2007 Oct;323(1):398-405. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
J-30 Related Classifications
HY-119118 Related Classifications
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