918504-27-5
Chemical Structure
B-Raf IN 11
- CAS No.: 918504-27-5
- Formula:C17H14BrF2N3O3S
- Molecular Weight:458.28
IUPAC Name: N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
InChIKey: TVFGCDQPUZGXMQ-UHFFFAOYSA-N
SMILES: FC1=C(C(C2=CNC3=NC=C(Br)C=C32)=O)C(F)=C(NS(=O)(CCC)=O)C=C1
Biological Activity: B-Raf IN 11 is a B-RafV600E mutant kinase inhibitor with an IC50 of 76 nM, and exhibits an IC50 of 238 nM against wild-type B-Raf kinase. B-Raf IN 11 inhibits the kinase activities of B-RafV600E mutant and wild-type B-Raf kinase. B-Raf IN 11 is applicable to relevant research on colorectal cancer[1].
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B-Raf IN 11 | 99.46% | B-Raf IN 11 is a B-RafV600E mutant kinase inhibitor with an IC50 of 76 nM, and exhibits an IC50 of 238 nM against wild-type B-Raf kinase. B-Raf IN 11 inhibits the kinase activities of B-RafV600E mutant and wild-type B-Raf kinase. B-Raf IN 11 is applicable to relevant research on colorectal cancer. | ||||||||||||||||||||
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Keywords
