919010-22-3
Chemical Structure
Pfn1-IN-2
- CAS No.: 919010-22-3
- Formula:C18H13N7O2
- Molecular Weight:359.34
IUPAC Name: 9-(3-hydroxyphenyl)-8-phenyl-4,9-dihydrotetrazolo[1',5':1,2]pyrimido[4,5-d]pyridazin-5(6H)-one
InChIKey: DQCXJOOFUDXXKT-UHFFFAOYSA-N
SMILES: O=C1NN=C(C2=C1NC3=NN=NN3C2C4=CC=CC(O)=C4)C5=CC=CC=C5
Biological Activity: Pfn1-IN-2 is an inhibitor of Profilin1 (Pfn1) and has the activity to interfere with the interaction between Pfn1 and actin. Pfn1-IN-2 can significantly reduce the overall level of intracellular filamentous (F) actin. Pfn1-IN-2 also slows down the migration and proliferation of endothelial cells (EC). Pfn1-IN-2 can inhibit the angiogenic ability of endothelial cells both in vivo and in vitro[1].
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Pfn1-IN-2 | 99.86% | Pfn1-IN-2 is an inhibitor of Profilin1 (Pfn1) and has the activity to interfere with the interaction between Pfn1 and actin. Pfn1-IN-2 can significantly reduce the overall level of intracellular filamentous (F) actin. Pfn1-IN-2 also slows down the migration and proliferation of endothelial cells (EC). Pfn1-IN-2 can inhibit the angiogenic ability of endothelial cells both in vivo and in vitro. | ||||||||||||||||||||
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Keywords
