931399-19-8
931399-19-8
Chemical Structure
GSK360A
- CAS No.: 931399-19-8
- Formula:C17H17FN2O5
- Molecular Weight:348.33
IUPAC Name: (1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine
InChIKey: TYHRZQVUPPODPT-UHFFFAOYSA-N
SMILES: O=C(CNC(C1=C(C2=C(C=CC(F)=C2)N(C1=O)CCC3CC3)O)=O)O
Biological Activity: GSK360A is a potent and orally active HIF-PHD inhibitor with IC50 values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. GSK360A activates the HIF-1 alpha pathway and protect the failing heart after myocardial infarction (MI) [1].
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GSK360A | 99.9% | GSK360A is a potent and orally active HIF-PHD inhibitor with IC50 values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. GSK360A activates the HIF-1 alpha pathway and protect the failing heart after myocardial infarction (MI) . | ||||||||||||||||||||
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References
Keywords
