GSK360A
Based on 1 Customer Validation
GSK360A is a potent and orally active HIF-PHD inhibitor with IC50 values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. GSK360A activates the HIF-1 alpha pathway and protect the failing heart after myocardial infarction (MI) .
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 931399-19-8
- Formula: C17H17FN2O5
- Molecular Weight:348.33
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male Lewis rats with ventricular dysfunction model[1]
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Dosage:30 mg/kg
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Administration:oral gavage
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Result:Increased circulating levels of erythropoietin and hemoglobin and hemoxygenase-1 expression in the heart and skeletal muscle of male rats.
Chemical Information
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CAS No. 931399-19-8
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Appearance Solid
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Molecular Weight 348.33
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Formula C17H17FN2O5
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Color White to off-white
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SMILES
O=C(CNC(C1=C(C2=C(C=CC(F)=C2)N(C1=O)CCC3CC3)O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 35 mg/mL (100.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8708 mL | 14.3542 mL | 28.7084 mL | 71.7710 mL |
| 5 mM | 0.5742 mL | 2.8708 mL | 5.7417 mL | 14.3542 mL | |
| 10 mM | 0.2871 mL | 1.4354 mL | 2.8708 mL | 7.1771 mL | |
| 15 mM | 0.1914 mL | 0.9569 mL | 1.9139 mL | 4.7847 mL | |
| 20 mM | 0.1435 mL | 0.7177 mL | 1.4354 mL | 3.5886 mL | |
| 25 mM | 0.1148 mL | 0.5742 mL | 1.1483 mL | 2.8708 mL | |
| 30 mM | 0.0957 mL | 0.4785 mL | 0.9569 mL | 2.3924 mL | |
| 40 mM | 0.0718 mL | 0.3589 mL | 0.7177 mL | 1.7943 mL | |
| 50 mM | 0.0574 mL | 0.2871 mL | 0.5742 mL | 1.4354 mL | |
| 60 mM | 0.0478 mL | 0.2392 mL | 0.4785 mL | 1.1962 mL | |
| 80 mM | 0.0359 mL | 0.1794 mL | 0.3589 mL | 0.8971 mL | |
| 100 mM | 0.0287 mL | 0.1435 mL | 0.2871 mL | 0.7177 mL |
GSK360A Related Classifications
HY-123422 Related Classifications
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