939040-79-6
Chemical Structure
TRPV1 antagonist 9
- CAS No.: 939040-79-6
- Formula:C22H19F3N6O3
- Molecular Weight:472.42
IUPAC Name: 3-amino-5-((2-((2-methoxyethyl)amino)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)oxy)quinoxalin-2(1H)-one
InChIKey: TUMYQRZCVIQKOQ-UHFFFAOYSA-N
SMILES: NC1=NC(C(NC1=O)=CC=C2)=C2OC3=NC(NCCOC)=NC(C4=CC=C(C(F)(F)F)C=C4)=C3
Biological Activity: TRPV1 antagonist 9 (compound 13c) is an orally active transient receptor potential vanilloid 1 (TRPV1) channel antagonist. TRPV1 antagonist 9 blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 values are 0.6 and 0.8 nM for Capsaicin (HY-10448) and acid-induced Ca2+ uptake, respectively. TRPV1 antagonist 9 blocks Capsaicin (HY-10448)-induced flinch response and causes hyperthermia in rats[1].
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TRPV1 antagonist 9 | TRPV1 antagonist 9 (compound 13c) is an orally active transient receptor potential vanilloid 1 (TRPV1) channel antagonist. TRPV1 antagonist 9 blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 values are 0.6 and 0.8 nM for Capsaicin (HY-10448) and acid-induced Ca2+ uptake, respectively. TRPV1 antagonist 9 blocks Capsaicin (HY-10448)-induced flinch response and causes hyperthermia in rats. | |||||||||||||||||||||
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Keywords
