944560-34-3
Chemical Structure
GDP-azido-fucose disodium
- CAS No.: 944560-34-3
- Formula:C16H22N8Na2O15P2
- Molecular Weight:674.32
InChIKey: QSWSRBVHHCEAAX-JLTDHLQRSA-L
SMILES: O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]4O[C@H]([C@H]([C@H]([C@@H]4O)O)O)CN=[N+]=[N-])(O[Na])=O)(O[Na])=O)O3)C=N2)NC(N)=N1
Biological Activity: GDP-azido-fucose disodium is a glycoengineering tool. GDP-azido-fucose disodium modifies complex glycans by adding an azido-fucose group. GDP-azido-fucose disodium can install azido-fucose tags on antibody Fc glycans for site-specific payload conjugation, thereby forming antibody-drug conjugates with defined ratios[1][2].
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GDP-azido-fucose disodium | 99.53% | GDP-azido-fucose disodium is a glycoengineering tool. GDP-azido-fucose disodium modifies complex glycans by adding an azido-fucose group. GDP-azido-fucose disodium can install azido-fucose tags on antibody Fc glycans for site-specific payload conjugation, thereby forming antibody-drug conjugates with defined ratios. | ||||||||||||||||||||
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- [1]. Shivatare VS, et al. Probing the Internalization and Efficacy of Antibody-Drug Conjugate via Site-Specific Fc-Glycan Labelling of a Homogeneous Antibody Targeting SSEA-4 Bearing Tumors. Israel journal of chemistry. 2023 Oct;63(10-11):e202300042. [Content Brief]
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[2]. Wu, Z. L., et al. (2020). Detecting substrate glycans of fucosyltransferases on glycoproteins with fluorescent fucose. bioRxiv, 2020-01.
Keywords
