955376-42-8
955376-42-8
Chemical Structure
MeS-IMPY
- CAS No.: 955376-42-8
- Formula:C16H17N3S
- Molecular Weight:283.39
InChIKey: WOYCDVDURLTMAW-UHFFFAOYSA-N
SMILES: CSC1=CN2C=C(C3=CC=C(N(C)C)C=C3)N=C2C=C1
Biological Activity: MeS-IMPY is a ligand of β-amyloid plaques. MeS-IMPY shows a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY (Ki=7.93 and 8.95 nM, respectively). [11C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET)[1][2].
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MeS-IMPY | MeS-IMPY is a ligand of β-amyloid plaques. MeS-IMPY shows a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY (Ki=7.93 and 8.95 nM, respectively). [11C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET). | |||||||||||||||||||||
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References
- [1]. Seneca N, et al. Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques. Nucl Med Biol. 2007 Aug;34(6):681-9. [Content Brief]
- [2]. Seneca N, et al. Low retention of [S-methyl-11C] MeS-IMPY to β-amyloid plaques in patients with Alzheimer's disease[J]. Current Radiopharmaceuticals, 2009, 2(2): 129-136.
Keywords
