959755-49-8
Chemical Structure
3'-O-(2-Nitrobenzyl)-dGTP
- CAS No.: 959755-49-8
- Formula:C17H21N6O15P3
- Molecular Weight:642.30
InChIKey: RMBWCTPPXMZHGM-YNEHKIRRSA-N
SMILES: OP(OC[C@H]1O[C@@H](N2C(NC(N)=NC3=O)=C3N=C2)C[C@@H]1OCC4=CC=CC=C4[N+]([O-])=O)(OP(OP(O)(O)=O)(O)=O)=O
Biological Activity: 3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dGTP can be recognized and incorporated by DNA polymerases, thereby temporarily terminating DNA primer extension; after the 2-nitrobenzyl blocking group is removed via laser irradiation, a free 3'-OH can be regenerated to allow subsequent polymerase-mediated extension. 3'-O-(2-Nitrobenzyl)-dGTP can be used in DNA sequencing studies[1].
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3'-O-(2-Nitrobenzyl)-dGTP | 3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dGTP can be recognized and incorporated by DNA polymerases, thereby temporarily terminating DNA primer extension; after the 2-nitrobenzyl blocking group is removed via laser irradiation, a free 3'-OH can be regenerated to allow subsequent polymerase-mediated extension. 3'-O-(2-Nitrobenzyl)-dGTP can be used in DNA sequencing studies. | |||||||||||||||||||||
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Keywords
