2. Stem Cell/Wnt TGF-beta/Smad Immunology/Inflammation
  3. TGF-beta/Smad Interleukin Related
  4. CBT-295

CBT-295 is an orally active autotaxin (ATX) inhibitor. CBT-295 exhibits a significant reduction in inflammatory cytokines like TGF-β, TNF-α and IL-6 levels, also reduced bile duct proliferation marker CK-19 and lowered liver fibrosis. The reversal of liver fibrosis with CBT-295 led to a reduction in blood and brain ammonia levels. CBT-295 also reduced neuroinflammation induced by ammonia. CBT-295 is promising for research of liver cirrhosis and associated encephalopathy.

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CBT-295

CBT-295 Estructura química

No. CAS : 1623794-90-0

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

CBT-295 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Interleukin Related:

Ver todas las isoformas
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Descripciòn

CBT-295 is an orally active autotaxin (ATX) inhibitor. CBT-295 exhibits a significant reduction in inflammatory cytokines like TGF-β, TNF-α and IL-6 levels, also reduced bile duct proliferation marker CK-19 and lowered liver fibrosis. The reversal of liver fibrosis with CBT-295 led to a reduction in blood and brain ammonia levels. CBT-295 also reduced neuroinflammation induced by ammonia. CBT-295 is promising for research of liver cirrhosis and associated encephalopathy[1].

Peso molecular

329.82

Fòrmula

C18H20ClN3O
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(C)N(CCCCC)C2=NC(C3=CC=C(Cl)C=C3)=CN12
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (151.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0320 mL 15.1598 mL 30.3196 mL
5 mM 0.6064 mL 3.0320 mL 6.0639 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0320 mL 15.1598 mL 30.3196 mL 75.7989 mL
5 mM 0.6064 mL 3.0320 mL 6.0639 mL 15.1598 mL
10 mM 0.3032 mL 1.5160 mL 3.0320 mL 7.5799 mL
15 mM 0.2021 mL 1.0107 mL 2.0213 mL 5.0533 mL
20 mM 0.1516 mL 0.7580 mL 1.5160 mL 3.7899 mL
25 mM 0.1213 mL 0.6064 mL 1.2128 mL 3.0320 mL
30 mM 0.1011 mL 0.5053 mL 1.0107 mL 2.5266 mL
40 mM 0.0758 mL 0.3790 mL 0.7580 mL 1.8950 mL
50 mM 0.0606 mL 0.3032 mL 0.6064 mL 1.5160 mL
60 mM 0.0505 mL 0.2527 mL 0.5053 mL 1.2633 mL
80 mM 0.0379 mL 0.1895 mL 0.3790 mL 0.9475 mL
100 mM 0.0303 mL 0.1516 mL 0.3032 mL 0.7580 mL
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CBT-295 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBT-2951623794-90-0CBT295CBT 295TGF-beta/SmadInterleukin RelatedTransforming growth factor betaILATXTGF-βTNF-αIL-6CK-19liver fibrosisammonia levelsneuroinflammationliver cirrhosis and associated encephalopathyInhibitorinhibitorinhibit

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Nombre del producto:
CBT-295
Cat. No.:
HY-169004
Cantidad:
MCE Japan Authorized Agent:

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