Pth - parathyroid hormone Gene

Also Known as Pth1; Pthr1; PTH-(1-84)

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24694

Summary

Enables hormone activity; peptide hormone receptor binding activity; and type 1 parathyroid hormone receptor binding activity. Involved in several processes, including Rho protein signal transduction; negative regulation of chondrocyte differentiation; and regulation of bone mineralization. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and cellular calcium ion homeostasis. Located in extracellular space. Used to study several diseases, including chronic kidney disease; hyperphosphatemia; nephrocalcinosis; osteoporosis; and secondary hyperparathyroidism. Biomarker of autosomal dominant hypocalcemia; kidney failure (multiple); osteoporosis; and secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including chronic kidney disease; diabetes mellitus (multiple); familial isolated hypoparathyroidism; hyperphosphatemia; and secondary hyperparathyroidism. Orthologous to human PTH (parathyroid hormone). [provided by Alliance of Genome Resources, Apr 2022]

Pth Products (1)

mRNA Protein Name
NM_017044.1 NP_058740.1 parathyroid hormone precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables hormone activity IMP
IMP: Inferred from mutant phenotype
11604398 RGD
enables parathyroid hormone receptor binding IDA
IDA: Inferred from direct assay
11554727 RGD
enables peptide hormone receptor binding IMP
IMP: Inferred from mutant phenotype
11604398 RGD
enables receptor ligand activity IMP
IMP: Inferred from mutant phenotype
11604398 RGD
enables type 1 parathyroid hormone receptor binding IDA
IDA: Inferred from direct assay
9054374 RGD
enables type 1 parathyroid hormone receptor binding IMP
IMP: Inferred from mutant phenotype
11604398 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
15476589 RGD
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9832460 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11604398 RGD
involved in cell-cell signaling IDA
IDA: Inferred from direct assay
22696456 RGD
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
9832460 RGD
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
9832460 RGD
involved in negative regulation of bone mineralization involved in bone maturation IMP
IMP: Inferred from mutant phenotype
11604398 RGD
involved in negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
11604398 RGD
involved in positive regulation of bone mineralization IDA
IDA: Inferred from direct assay
15758479 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
8603605 RGD
involved in positive regulation of ossification IDA
IDA: Inferred from direct assay
15758479 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
22708652 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23376407 RGD
involved in response to fibroblast growth factor IEP
IEP: Inferred from expression pattern
23467972 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
23376407 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
22677883 RGD
involved in response to parathyroid hormone IEP
IEP: Inferred from expression pattern
9639577 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
22926202 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
22260362 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
23094155 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

parathyroid hormone

  • hypothalamic parathyroid hormone

  • parathyrin

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (7)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P0059 Teriparatide Agonist 99.98% Unkown
HY-P1955A Etelcalcetide hydrochloride Activator 99.80% Unkown
HY-17613 Evocalcet Activator 99.28% Unkown
HY-109106A Upacicalcet sodium Agonist 99.91% Unkown
HY-P1955 Etelcalcetide Activator / Unkown
HY-109106 Upacicalcet Agonist / Unkown
HY-P0059A Teriparatide acetate hydrate Agonist / Unkown

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P10909 Canvuparatide Agonist 95.48% Phase 2
HY-100856 PCO371 Agonist 99.67% Phase 1

Pre-clinical Phase

Bioactive Molecules (55)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-112171 γ-L-Glutamyl-L-alanine Modulator 98.0% Unkown
HY-P4385 (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) Antagonist 99.77% Unkown
HY-P1852 TIP 39, Tuberoinfundibular Neuropeptide 99.84% Unkown
HY-P2426 (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) Antagonist 99.70% Unkown
HY-P3075 pTH-Related Protein (1-34) (human,mouse,rat) 99.64% Unkown
HY-P4821 pTH (1-34) amide (human) 99.78% Unkown
HY-P4823 pTH (1-37) (human) Activator 99.91% Unkown
HY-P1418A DPC-AJ1951 TFA Agonist 99.38% Unkown
HY-P4697A pTH (44-68) (human) TFA 99.45% Unkown
HY-P10078 pTH (39-84) (human) Activator 98.88% Unkown
HY-P1252 Parathyroid Hormone (1-34), bovine Agonist 99.88% Unkown
HY-112171R γ-L-Glutamyl-L-alanine (Standard) Modulator 99.29% Unkown
HY-P4697 pTH (44-68) (human) / Unkown
HY-P4701 pTH-Related Protein (1-34) amide (human, mouse, rat) 99.35% Unkown
HY-P4715 (Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) 99.08% Unkown
HY-RS11395 PTH1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10003A 1α-Hydroxy-3-epi-vitamin D3 Inhibitor 99.30% Unkown
HY-109106B (Rac)-Upacicalcet 95.0% Unkown
HY-15106 SB-423557 Antagonist / Unkown
HY-176943 PTH1R agonist 1 Agonist / Unkown
HY-176944 PTH1R agonist 2 Agonist / Unkown
HY-176945 PTH1R agonist 3 Agonist / Unkown
HY-32351B 3-epi-Calcifediol / Unkown
HY-NP227 PTH Protein, human / Unkown
HY-P0059S Teriparatide-d10 / Unkown
HY-P10309 [Nle8,18,Tyr34]-pTH (3-34) amide (human) Ligand / Unkown
HY-P1252A Parathyroid Hormone (1-34), bovine TFA Agonist / Unkown
HY-P1418 DPC-AJ1951 Agonist / Unkown
HY-P4690 pTH (13-34) (human) / Unkown
HY-P4692 pTH (1-44) (human) / Unkown
HY-P4696 pTH (3-34) (bovine) / Unkown
HY-P4700 pTH (53-84) (human) / Unkown
HY-P4817 Human PTH-(1-31) / Unkown
HY-P4818 Human PTH-(1-31) amide / Unkown
HY-P4827 pTH (1-84) (dog) Agonist / Unkown
HY-P4835 pTH (2-34) (human) / Unkown
HY-P4849 pTH-Related Protein (1-37) (human, mouse, rat) Activator / Unkown
HY-P4856 pTH-Related Protein (1-40) (human, mouse, rat) Activator / Unkown
HY-P4857 pTH-Related Protein (7-34) amide (human, mouse, rat) / Unkown
HY-RS11394 PTH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11396 PTH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11397 PTH2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11454 PTRH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W282259 PTH-tyrosine / Unkown
HY-122075 FR 78844 / Unkown
HY-171446 TAK-075 Antagonist / Unkown
HY-17613S Evocalcet-d4 Activator / Unkown
HY-176946 PTH1R agonist 4 Agonist / Unkown
HY-179356 Octadecyl β-D-glucopyranosiduronic acid Activator / Unkown
HY-RS16633 Pth Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17667 Pth1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20090 Pth2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23068 Pth Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24128 Pth1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26593 Pth2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P991361 ABX-10241 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pth NCBI NCBI:5741