1. Vitamin D Related/Nuclear Receptor
  2. Thyroid Hormone Receptor
  3. 1α-Hydroxy-3-epi-vitamin D3

1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion.

For research use only. We do not sell to patients.

1α-Hydroxy-3-epi-vitamin D3 Chemical Structure

1α-Hydroxy-3-epi-vitamin D3 Chemical Structure

CAS No. : 58028-00-5

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1 mg USD 550 In-stock
5 mg USD 1450 In-stock
10 mg USD 2450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion[1].

In Vitro

1 alpha, 25(OH)2D3 is an important negative regulator of parathyroid hormone (PTH) gene transcription[1]. In ROS 17/2.8 cells, 1α-OHD3 (10 μM) not only metabolized into 1αOH-3-epi-D3 and 1α,25(OH)2D3 but also 1α,25(OH)2-3-epi-D3[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

400.64

Formula

C27H44O2

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@H](C\3)O)O)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (124.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4960 mL 12.4800 mL 24.9601 mL
5 mM 0.4992 mL 2.4960 mL 4.9920 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4960 mL 12.4800 mL 24.9601 mL 62.4002 mL
5 mM 0.4992 mL 2.4960 mL 4.9920 mL 12.4800 mL
10 mM 0.2496 mL 1.2480 mL 2.4960 mL 6.2400 mL
15 mM 0.1664 mL 0.8320 mL 1.6640 mL 4.1600 mL
20 mM 0.1248 mL 0.6240 mL 1.2480 mL 3.1200 mL
25 mM 0.0998 mL 0.4992 mL 0.9984 mL 2.4960 mL
30 mM 0.0832 mL 0.4160 mL 0.8320 mL 2.0800 mL
40 mM 0.0624 mL 0.3120 mL 0.6240 mL 1.5600 mL
50 mM 0.0499 mL 0.2496 mL 0.4992 mL 1.2480 mL
60 mM 0.0416 mL 0.2080 mL 0.4160 mL 1.0400 mL
80 mM 0.0312 mL 0.1560 mL 0.3120 mL 0.7800 mL
100 mM 0.0250 mL 0.1248 mL 0.2496 mL 0.6240 mL
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1α-Hydroxy-3-epi-vitamin D3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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1α-Hydroxy-3-epi-vitamin D3
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