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  3. DPC-AJ1951

DPC-AJ1951 

Cat. No.: HY-P1418
Handling Instructions

DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) , and characterized its activity in ex vivo and in vivo assays of bone resorption.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DPC-AJ1951 Chemical Structure

DPC-AJ1951 Chemical Structure

CAS No. : 943519-33-3

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Other Forms of DPC-AJ1951:

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Description

DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) , and characterized its activity in ex vivo and in vivo assays of bone resorption[1].

In Vitro

DPC-AJ1951 induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR (EC50 26±14 nM)[1][1].

Molecular Weight

448.45

Formula

C₁₇H₂₉FN₆O₇

CAS No.

943519-33-3

Sequence

{Aib}-Val-{Aib}-Glu-Ile-Gln-Leu-{Nle}-His-Gln-Arg-Ala-Lys-Tyr-NH2

Sequence Shortening

{Aib}V{Aib}EIQL{Nle}HQRAKY-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DPC-AJ1951Thyroid Hormone ReceptorTHRparathyroidhormonePTHPPRboneresorptionInhibitorinhibitorinhibit

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Product name:
DPC-AJ1951
Cat. No.:
HY-P1418
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